Investigating the Frequency of Delta 32 (∆32) Mutation Related to CCR5 Chemokine Receptor in Patients at Gonabad Health Centers, Iran

Aims Chemokine receptor type 5 is recognized as the main co-receptor in HIV infection. Many studies have shown that deletion of 32-base pairs (bp) both alleles CCR5 leads to reduction or elimination expression this gene immune cells and natural resistance This study aims determine frequency delta 32 mutations healthy people, referring health center Gonabad City, Iran, focus on finding new treatment methods for HIV. Methods & Materials In descriptive cross-sectional study, after obtaining ethical approval informed consent, blood samples were collected from 293 people along with ethylenediaminetetraacetic acid anticoagulant. Genomic DNA extraction was carried out by kit, investigation (∆32) mutation investigated via polymerase chain reaction method. Findings Our results showed who referred center, 269 (91.8%) had a without (188 bp), 15 (5.1%) heterozygous bp 156 9 (3.07%) homozygous (156 bp). Conclusion Based results, rate Region, studied community higher compared similar studies, more epidemiological molecular are needed better conclusions.